Doppel, a prion-like protein, is a GPI-membrane anchored protein generally not expressed in the Central Nervous System (CNS) of different mammalian species, including human.Nevertheless, in astrocytomas, a particular kind of glial tumors, the doppel encoding gene (PRND) is over-expressed and the corresponding protein product (Dpl) is ectopically lo
Excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR) is believed to be a primary mechanism of neuronal injury following stroke.Thus, many drugs and therapeutic peptides were developed to inhibit either the NMDAR at the cell surface or its downstream intracellular death-signaling cascades.Nevertheless, the majority of focal ischemia
Abstract Anthropogenic activities like trade facilitate increasing rates of biological invasions.Asian long-horned beetle (ALB), which is naturally distributed in eastern Asia (China, Korean peninsula), was introduced via wood packing materials (WPM) used in trade to North America (1996) and Europe (2001).We used 7810 single nucleotide polymorphism
Ducted propeller is a kind of special propeller widely used in unmanned underwater vehicles, its flow characteristics and hydrodynamic noise are very important for marine environmental protection and equipment concealment.The hybrid techniques based on the acoustic analogy theory are adopted in the present study to calculate the unsteady flow field
In response to odour regulation for solid waste management installations in France a web based tool was developed to monitor odour impacts using volunteer community field panels, spontaneous resident observations and professional panels.This approach has been used for some time in France, and allows close monitoring of the impact of new waste manag